Evaluation of smooth muscle relaxant potential of Bismarckia nobilis (Hildebr. & Wendl.) in diarrhea, hypertension and asthma by ex-vivo and in-vivo method

  • Fatima Saqib
  • Naila Jabeen
  • Muhammad Riaz
  • Gabriela Sechel
Palabras clave: Bismarckia nobilis; Spasmolytic activity; Anti-asthmatic activity; Hypotensive; Diarrhea; Calcium channel blocker

Resumen

To explore the mechanistic basis behind smooth muscle relaxant prospective of Bismarckia nobilis in gastrointestinal, respiratory and cardiovascular ailments. The methanolic extract of B. nobilis and sub-fractions have been evaluated in vitro rabbit isolated tissues, in vivo castor oil-induced diarrhea in rats and charcoal meal activity in mice. The B. nobilis extract relaxed spontaneous and K+ (80 mM)- induced contractions in rabbit isolated jejunum preparations, CCh (1 μM) and K+ (80 mM)-induced contractions in tracheal and bladder preparations, PE (1 μM) and K+ (80 mM)-induced concentrations in aorta preparations, likewise verapamil. Spasmolytic activity of dichloromethane fraction is stronger as compared to aqueous fraction. In vivo castor oil-induced diarrhea in rats and charcoal meal activity in mice further supported spasmolytic activity. B. nobilis extract possess anti-spasmodic, anti-diarrheal, airway relaxant and vasodilator activities possible mediated through calcium channel blocking mechanism, justifying therapeutic utility of B. nobilis in diarrhea, asthma and hypertension.

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Publicado
2019-04-14
Sección
Artículos | Articles