Chemical composition, in vitro cytotoxic and antioxidant activities of the essential oil of Peruvian Minthostachys mollis Griseb

  • Julio Benites
  • Angélica Guerrero Castilla
  • Felipe Salas
  • José L. Martinez
  • Rafael Jara Aguilar
  • Edmundo A. Venegas Casanova
  • Luz Suarez Rebaza
  • Juana Guerrero Hurtado
  • Pedro Buc Calderón
Palabras clave: Minthostachys mollis, Essential oil, Chemical composition, Cytotoxicity, Antioxidant activity, Lamiaceae


The composition of the essential oil obtained by hydrodistillation from Minthostachys mollis Griseb (Lamiaceae) aerial parts was determined by GC and GC/MS. Menthone (13.2%), pulegone (12.4%), cis-dihydrocarvone (9.8%) and carvacrol acetate (8.8%) were the main essential oil components. The cytotoxic activity of the essential oil was in vitro measured using the MTT colorimetric assay. IC50values were calculated on healthy non-tumor cells (HEK-293) and three human cancer cell lines (T24, DU-145 and MCF-7). In such latter cells, the estimated values were around 0.2 mg/mL. In addition, the antioxidant activity was determined by interaction with the stable freeradical 2,2”-diphenyl-1-picrylhydrazyl. The essential oil was almost devoid of antioxidant activity indicating that its anti-proliferative action relies on other unknown mechanism.


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